Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys - Arg and Lys - Val bonds

generates cleavage sites at Lys Arg and Lys Val bonds Annette Schmidt, Frank Echtermeyer, Anthony Alozie, Kerstin Brands and Eckhart Buddecke Institute of Arteriosclerosis Research, Department of Physiological Chemistry and Pathobiochemistry, University Hospital Muenster, Germany Running title: Protease mediated shedding of syndecan-4 Address correspondence to: Annette Schmidt, Institute of Arteriosclerosis Research, Department of Molecular Cardiology, Domagkstr. 3, D-48149 Muenster, Germany, Phone: +49-251835 8626, Fax: +49-251-835 8628, E-mail: [email protected]